Prof. Osamu TABATA
IEEE Fellow, IEEJ Fellow
Kyoto University of Advanced Science, Japan
Sacrificial DNA Origami Technique for Nanosensing
Abstract: A new approach utilizing DNA origami (DO) as a sacrificial nanostructure is proposed. As a demonstration of the proposed technique, a surface-enhanced Raman spectroscopy (SERS) device utilizing gold nanoparticle (AuNP) dimer structure with nanogap for single-molecule label-free detection was fabricated. In this approach, 15-nm diameter AuNPs are precisely self-assembled to form a dimer structure on opposite faces of a DO structure. The AuNPs are then fixed on a silicon chip followed by the selective removal of DO by vacuum ultraviolet (VUV) treatment and subsequent ultrapure water cleaning. X-ray photoelectron spectroscopy measurements confirmed the successful removal of the DNA nano-structures and the VUV treatment had little effect on the diameter of the AuNPs. Quantitative evaluations showed that the original gap distance of about 3.8 nm was reduced to less than 2 nm after the DO structures were removed by the VUV treatment and ultrapure water rinse. It was demonstrated that the Raman signals from 4,4'-bipyridine used as a target molecule were highly enhanced and detected successfully. The proposed technique can therefore be considered as a promising simple and low-cost alternative to EB lithography approaches.
Bio: Osamu Tabata received his M.S. and Ph.D. degrees from Nagoya Institute of Technology, Japan, in 1981 and 1993, respectively. In 1981, he joined the Toyota Central Research and Development Laboratories, Inc., Japan. In 1996, he joined the Department of Mechanical Engineering, Ritsumeikan University, Japan. In 2003, he moved to the Graduate School of Engineering, Kyoto University, Japan. October 2019, he moved to Kyoto University of Advanced Science as a founding Dean of Faculty of Engineering and Graduate School of Engineering. From Dec. 2022, he was also served as an Executive Vice President. He has been engaged in research on micro/nano processes, MEMS, DNA Nanotechnology.
Prof. Tabata was a guest
professor at the Department of Microsystem
Engineering, University of Freiburg, Germany from
September to December 2000, a guest Professor of ETH
Zurich, Switzerland from January to March 2001, a
visiting senior international scientist of the
Chinese Academy of Science in 2010, a guest
Professor of Huazhong University of Science and
Technology, China from July 2011 to July 2014, a
senior research fellow at the Freiburg Institute for
Advanced Studies (FRIAS) from May 2010 to September
2012, a distinguished visiting researcher of
American University in Cairo in 2016 and a visiting
Professor of Tsinghua University China from November
2018. He is a senior editor of the IEEE Transactions
on Nanotechnology (TNANO), an associate editor of
the ASME/IEEE Journal of Micro Electro Mechanical
Systems (JMEMS), and an editorial board member of
the Elsevier Journal Sensors and Actuators. He is
also a program committee member of many important
International Conferences in his area of expertise.
From 2020, he is an Award Committee Member for EDS
IEEE. He is a Fellow of Institute of Electrical and
Electronics Engineers (IEEE) and Institute of
Electrical Engineer Japan (IEEJ).
Prof. Zengtao Chen
Fellow of American Society of Mechanical Engineers (ASME) and Canadian Society for Mechanical Engineering (CSME)
Tenured Professor in the Department of Mechanical Engineering
University of Alberta, Canada
Bio: Professor Zengtao Chen is a tenured professor in the Department of Mechanical Engineering of University of Alberta. He got his first PhD in solid mechanics from Harbin Institute of Technology in 1995 and second PhD in mechanical engineering from University of Waterloo in 2004. He has been a faculty member at Harbin Institute of Technology (1990-1995), Tsinghua University 1996-1998), and University of New Brunswick (2004-2014, including two years as Chair of the Department of Mechanical Engineering) prior to the current position. He is an elected Fellow of American Society of Mechanical Engineers (ASME) and Canadian Society for Mechanical Engineering (CSME). He is a registered professional engineer in Alberta. Dr. Chen’s research areas include Mechanics of Materials, Materials Modelling, and Damage and Fracture Mechanics. His recent interests are in multiscale modelling of deformation and damage evolution in metal forming processes, advanced thermal stress analysis of smart materials and structures, and composite structures. Dr. Chen has published more than 270 journal papers, three books, numerous conference papers, and delivered more than 120 invited and keynote speeches in various institutions and international conferences. Dr. Chen is a recipient of many awards, such as the Humboldt Research Fellowship Award (1999), HIWIN Supervisor Award for Best Doctoral Dissertation in Mechanical Engineering (2019), International Journal of Applied Mechanics 6-year most cited paper award (2015), CSME Best Presentation Awards (2011, 2017), UNB Research Scholarship (2012, two faculty members each year), UNB Teaching Excellence Award (2012), and UNB Merit Award (2007, 2013), Harrison McCain Foundation Young Scholar Award (2007), CIM Light-weight Alloys Best Paper Award (2005), and New Brunswick Innovation Foundation Research Award (2005), etc. Dr. Chen has trained more than 80 graduate students and post-doctoral fellows, and many of them became academics in renowned institutions, including McGill, Waterloo, NRC, Nagoya, Lanzhou, and Nanjing, etc. Dr. Chen has served for many organizations and conferences, including Natural Sciences and Engineering Research Council of Canada, Canadian Engineering Accreditation Board, International Congress on Fracture, and Professional Engineers of Ontario.